The COVID-19 outbreak has drastically changed the social, economic and health landscape throughout the world. The virus, which was first detected in Wuhan, China, at the end of 2019, spread rapidly, causing an unprecedented global health crisis. The global impact of this outbreak is far-reaching, encompassing more than just viral infections. In the health sector, COVID-19 is pushing health systems in many countries to their limits. Hospitals are beginning to be overwhelmed by the ever-increasing number of patients, while medical personnel battle fatigue and the risk of infection. The World Health Organization (WHO) responded by issuing public health guidelines to reduce the spread of the virus, including the use of masks and the implementation of physical distancing. From an economic perspective, COVID-19 triggered a global recession due to business closures and mobility restrictions. Many companies were forced to reduce their workforce, which drastically increased unemployment rates. The tourism and transportation sectors experienced severe contractions, with implications for state revenues. Economic recovery efforts have become a priority for many countries, with fiscal and monetary stimulus. The social impact of COVID-19 is also very significant, changing the way individuals interact. Social distancing causes isolation, increases mental health problems and damages social networks. Children and teenagers are forced to learn from home, which has an impact on the quality of their education. Social injustice is also increasingly visible, with vulnerable and low-income groups facing higher risks of infection and economic impact. The coping strategies implemented vary between countries. Some countries have successfully implemented strict lockdown policies, while others have chosen a looser approach with a focus on vaccination. The global vaccination program, led by WHO and the COVAX initiative, aims to provide vaccine access to low- and middle-income countries. Mass vaccination has proven to be a key strategy in reducing transmission and minimizing disease severity. The application of technology also plays an important role in the COVID-19 response strategy. The development of contact tracing applications and the use of public health data for epidemiological analysis improves the health response. Telemedicine has emerged as an alternative solution to provide health services without physical contact, reducing the risk of spreading the virus. The community also plays an active role in dealing with this epidemic. Awareness of the importance of implementing health protocols, such as washing hands and using masks, is increasing. Information campaigns organized by governments and non-governmental organizations are an important tool in educating the public about the risks and prevention of COVID-19. However, challenges remain, such as the emergence of new variants of the SARS-CoV-2 virus which can reduce the effectiveness of vaccines. Therefore, research and development of vaccines and medicines must continue to be encouraged, to overcome the risk of future infections. The involvement of the international community in sharing information and technology is essential to create more effective response strategies. Therefore, even though the threat of COVID-19 still exists, various mitigation efforts implemented throughout the world show hope for a return to normal conditions. Health, economy and social are three pillars that must continue to be maintained and strengthened for a better global future.